In which tissue would you find no nociceptors?

• A. Brain itself
• B. Meninges
• C. Spinal cord
• D. Nerves

Answer: (A)

Nociceptors are specialized free nerve endings that detect tissue damage and send pain signals. The brain tissue itself does not contain these pain receptors, so brain parenchyma cannot generate pain internally. Pain sensations from brain-related issues come from surrounding structures, especially the meninges and blood vessels, which do have nociceptors. Other tissues mentioned—meninges, spinal cord, and peripheral nerves—do possess nociceptors, so they can sense painful stimuli. Therefore, the tissue with no nociceptors is the brain itself.